Grant McClelland index MacMaster

Full publication list also available from Pubmed

  1. Lyons SA, and McClelland GB. (2022) Thermogenesis is supported by high rates of circulatory fatty acid and triglyceride delivery in highland deer mice. J Exp Biol. May 13:jeb.244080. doi: 10.1242/jeb.244080. Inside JEB feature
  2. Hayward, L, Robertson, C.E., , and McClelland, G.B. (2022) Phenotypic plasticity to chronic cold exposure in two species of Peromyscus from different environments. J. Comp. Physiol. B. 192, pages335–348.
  3. Schippers, M.-P., Ramirez, O., Arana, M., and McClelland, G.B. (2021) Increased reliance on carbohydrates for aerobic exercise in highland Andean leaf-eared mice, but not in highland Lima leaf-eared mice. Metabolites, 11: 750. Special Issue "Metabolic Strategies in Hypoxia"
  4. Coulson, S.Z., Robertson, C.E., Mahalingam, S., and McClelland, G.B. (2021) Plasticity of non-shivering thermogenesis and brown adipose tissue in high-altitude deer mice. J. Exp. Biol., 224, jeb242279. doi:10.1242/jeb.242279. †Co-first authors
  5. Lyons, SA, Tate, K.B., Welch, K.C. Jr., and McClelland, G.B. (2021) Lipid oxidation during thermogenesis in high altitude deer mice. Am. J. Physiol. 320(5): R735-R746. DOI: 10.1152/ajpregu.00266.2020
  6. Robertson, C.E. and McClelland, G.B. (2021) Evolved changes in maternal care in high-altitude native deer mice. J. Exp. Biol., 224(7): jeb235218. DOI: 10.1242/jeb.235218
  7. Robertson, C.E. and McClelland, G.B. (2021). Ancestral and developmental cold alter brown adipose tissue function and adult thermal acclimation in Peromyscus. J. Comp. Physiol. B., 191:589–601, DOI: 10.1007/s00360-021-01355-z
  8. Blewett, T.A., Leonard, E.M., Glover, C.N., McClelland, G.B., Wood, C.M., McGeer, J.C., Santore, R.C., Smith, S.D. (2021). The effect of marine dissolved organic carbon on nickel accumulation in early life-stages of the sea urchin, Strongylocentrotus purpuratus. Comp. Physiol. Biochem. C., 250:109150.
  9. Mahalingam, S., Cheviron, Z.A., Storz, J.F., McClelland, G.B., and Scott, G.R. (2020). Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes. J. Physiol. 598(23): 5411-5426. [Journal cover]
  10. Tate, K.B., Wearing, O.H., Ivy, C.M., Cheviron, Z.A., Storz, J.F., McClelland, G.B., and Scott, G.R. (2020). Coordinated changes across the O2 cascade underlie adaptive increases in thermogenic capacity in high-altitude deer mice. Proc. Roy. Soc. B. 287: 20192750.
  11. Velotta, J.P., Robertson, C.E., Schweitzer, R.M, McClelland, G.B., and Cheviron, Z.A. (2020). Adaptive shifts in gene regulation underlie a developmental delay in thermogenesis in high-altitude deer mice. Mol. Biol. Evol. 37(8): 2309–2321
  12. Ivy, C.M., Greaves, M.A., Sangster, E.D., Robertson, C.E., Natarajan, C., Storz, J.F., McClelland, G.B., and Scott, G.R. (2020). Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude. J. Exp. Biol. 223, jeb219360
  13. Kulesza, A., Leonard, E.M., and McClelland, G.B. (2020) Influence of 96h sub-lethal copper exposure on aerobic scope and recovery from exhaustive exercise in killifish (Fundulus heteroclitus). Aquatic Toxicology. 218:105373
  14. Robertson, C.E. and McClelland, G.B. (2019). Developmental delay in shivering limits thermogenic capacity in juvenile high-altitude deer mice (Peromyscus maniculatus). J. Exp. Biol. 222, jeb210963.
  15. Robertson, C.E., Tattersall, G.J., and McClelland, G.B. (2019). Development of homeothermic endothermy is delayed in high altitude native deer mice (Peromyscus maniculatus). Proc. R. Soc. B. 286: 20190841.
  16. Storz, J.F., Cheviron, Z.A., McClelland, G.B., and Scott, G.R. (2019). Evolution of physiological performance capacities and environmental adaptation: insights from high-altitude deer mice (Peromyscus maniculatus). J. Mammal. 100(3):910-922. [invited review for the Journal’s 100th anniversary]
  17. McClelland, G.B., and Scott, G.R. (2019) Evolved mechanisms of aerobic performance and hypoxia resistance in high-altitude natives. Ann. Rev. Physiol. 81:561–583.
  18. Borowiec, B.G., McClelland, G.B., Rees, B.B., and Scott, G.R. (2018) Distinct metabolic adjustments arise from acclimation to constant hypoxia and intermittent hypoxia in estuarine killifish (Fundulus heteroclitus). J. Exp. Biol. 221
  19. Buck, L.T., Burness, G., Campbell, K, Darveau, C.-A., Driedzic, W., Guderley, H., McClelland, G.B., Moon, T.W., Moyes, C.D., and Schulte, P.M. (2018) 50 Years of comparative biochemistry: The legacy of Peter Hochachka, Comp. Biochem. Physiol. B. 224:1-11.
  20. Tate, K.B., Ivy, C.M., Velotta, J.P., Storz, J.F., Cheviron, Z.A., McClelland, G.B., and Scott, G.R. (2017) Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice. J. Exp. Biol. 220(20): 3616-3620
  21. McClelland, G.B., Lyons, S.A., and Robertson, C.E. (2017). Fuel use in mammals: conserved patterns and evolved strategies for aerobic locomotion and thermogenesis. Integr. Comp. Biol. 57(2):231-239.
  22. Salman, S., Vollmer, C., McClelland, G.B., and Nurse, C.A. (2017) Characterization of ectonucleotidase expression in the rat carotid body: Regulation by chronic hypoxia. Am. J. Physiol. 313(3):C274-C284.
  23. Storz, J.F. and McClelland, G.B. (2017) Rewiring metabolism under oxygen deprivation. Science. 356 (6335), 248-249
  24. Mahalingam, S., McClelland, G.B., and Scott, G.R. (2017) Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice. J. Physiol. 595(14): 4785–4801.
  25. Lau, D., Mahalingam, S., Connaty, A.D., Wall, N., Cheviron, Z.A., Storz, J.F., Scott, G.R., and McClelland, G.B. (2017) Acclimation to hypoxia increases carbohydrate use during exercise in high-altitude deer mice. Am. J. Physiol, Am. J. Physiol. 312: R400–R411.
  26. Blewett, T. Ransberry, V.E., McClelland, G.B., and Wood, C.M. (2016) Investigating the mechanisms of Ni uptake and sub-lethal toxicity in the Atlantic killifish Fundulus heteroclitus in relation to salinity. Environmental Pollution. 211:370-381.
  27. Ransberry V.E., Blewett, T.A., and McClelland, G.B. (2016) The Oxidative Stress Response in Freshwater-Acclimated Killifish, (Fundulus heteroclitus) to Acute Copper and Hypoxia Exposure. Comp Biochem Physiol C 179:11-18
  28. Ransberry, V.E., Morash, A.J., Blewett, T., Wood, C.M., and McClelland, G.B (2015) Oxidative stress and metabolic responses to copper in freshwater- and seawater-acclimated Killifish, Fundulus heteroclitus. Aquatic Toxicology 161: 242–252.
  29. Henry, M., Birceanu, O., Clifford, A., McClelland, G.B., Yang, Y., and Wilkie, M.P. (2015) Life-stage dependent responses to the lampricide, 3-trifluoromethyl-4-nitrophenol (TFM), provide insight into glucose homeostasis and metabolism in the sea lamprey (Petromyzon marinus). Comp Biochem Physiol C Toxicol Pharmacol. 169:35-45.
  30. Lui, M.A., Mahalingam, S., Patel, P., Connaty, A.D., Ivy, C.M., Cheviron, Z.A., Storz, J.F., McClelland, G.B., and Scott, G.R.(2015) High-altitude ancestry and hypoxia acclimation have distinct effects on exercise capacity and muscle phenotype in deer mice. Am. J. Physiol. 308:R779-R791.
  31. Morash, A.J., Vanderveken, M. and McClelland G.B. (2014) Muscle metabolic remodelling in response to endurance exercise and fasting in salmonids. Front. Physiol. 5:452.
  32. Schippers, M.P., Le Moine, C.M.R., and McClelland G.B. (2014) Patterns of fuel use during locomotion in mammals: the importance of aerobic scope. J. Exp. Biol. 217: 3193-3196.
  33. Cheviron, Z.A., Connaty A.D., McClelland G.B., and Storz J.F. (2014) Functional genomics of adaptation to hypoxic cold-stress in high-altitude deer mice: transcriptomic plasticity and thermogenic performance. Evolution 68 (1): 48-62.
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  34. Craig, P.M., Fitzpatrick, J.L., Walsh, P.J., Wood, C.M., and McClelland, G.B. (2014) Coping with hypoxia: How the plainfin midshipman (Porichthys notatus) survives the intertidal zone. Environ Biol Fish. . 97:163-172.
  35. Birceanu, O., Sorensen, L., Henry, M., McClelland, G.B., Yang, Y.S., and Wilkie, M.P. (2014). The effects of the lampricide 3-trifluoromethyl-4-nitrophenol (TFM) on fuel stores and ion balance in a non-target fish, the Rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol - C. 160:30-41.
  36. Morash, A.J., Le Moine, C.M.R., Yu, W., Hill, J. A., Patterson, D.A., Farrell, A.P., and McClelland, G.B. (2013) Genomic and metabolic preparation in sockeye salmon (Oncorhynchus nerka) for spawning migration. Physiol Biochem. Zool. 86(6):750-760.
  37. McClelland, G.B., and Scott, G.R. (2013) Muscle Plasticity. In: Evans, DH, Claiborne, J.B., and Currie, S (eds.). The Physiology of Fishes, 4th ed. CRC press, Baton Raton, Fl.
  38. Schippers, M.-P., Ramirez, O., Arana, M., Bernal, P.P., and McClelland, G.B. (2012) Increase in carbohydrate utilization in high-altitude Andean mice. Current Biology. 22(24):2350-2354.
  39. Templeman, N.M., Schultz, H., Garland, T., and McClelland, G.B. (2012) Do mice selectively bred for high locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise? Am. J. Physiol. 303:R101-R111.
  40. Cheviron, Z.A., Bachman, G.C., Connaty, A.D., McClelland, G.B., Storz, J.F. (2012) Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice. Proc. Natl. Acad. Sci., USA., 109(22):8635-40.
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  41. McClelland, G.B. (2012) Muscle Remodeling and the Exercise Physiology of Fish. Exerc. Sport Sci. Rev. 40(3):165-173.
  42. Morash, A.J., and McClelland, G.B. (2011) Regulation of carnitine palmitoyltransferase (CPT) I during fasting in rainbow trout (Oncorhynchus mykiss) promotes increased mitochondrial fatty acid oxidation. Physiol. Biochem. Zool. 84(6):625-33.
  43. Le Moine, C.M.R., Morash, A.J., and McClelland, G.B. (2011). Changes in HIF-1alpha protein, pyruvate dehydrogenase phosphorylation and activity with exercise in acute and chronic hypoxia. Am. J. Physiol. 301:R1098-R1104.
  44. McClelland, G.B. (2010). Cellular Respiration. In: Farrell A.P., (ed.), Encyclopedia of Fish Physiology: From Genome to Environment, volume 2, pp. 951-958. San Diego: Academic Press.
  45. Birceanu, O., McClelland, G.B., Yang, Y.S., Brown, J.C.L. and Wilkie, M.P. (2010). The Lampricide 3-Trifluoromethyl-4-Nitrophenol (TFM) Uncouples Mitochondrial Oxidative Phosphorylation in Both Sea Lamprey (Petromyzon marinus) and TFM-Tolerant Rainbow Trout (Oncorhynchus mykiss). Comp Biochem Physiol -C (in Press)
  46. Templeman, N.M., Beaudry, J.L., Le Moine, C.M.R., and McClelland, G.B. (2010) Chronic hypoxia- and cold-induced changes in cardiac enzyme and gene expression in CD-1 mice. Biochim Biophys Acta 1800(12):1248-55
  47. Beaudry, J.L., and McClelland, G.B. (2010) Thermogenic responses in CD-1 mice after combined chronic hypoxia and cold acclimation. Comp. Biochem. Physiol. B. 157:301-309.
  48. Morash, A.J., Le Moine, C.M.R., and McClelland, G.B. (2010) Genome duplication events have lead to a diversification in the CPT I gene family in fish. Am. J. Physiol. 299: R579 - R589.
  49. Craig, P.M., Wood, C.M., and McClelland, G.B. (2010) Water Chemistry alters gene expression and physiological endpoints of chronic waterborne copper exposure in zebrafish, Danio rerio. Environ. Sci. Tech. 44: 2156-2162
  50. Le Moine, C.M.R., Craig, P.M., Dhekney, K., Kim, J.J., and McClelland, G.B. (2010) Temporal and spatial patterns of gene expression in skeletal muscles in response to swim training in adult zebrafish (Danio rerio). J. Comp. Physiol. B. 180(1):151-60.
  51. Schippers, M.-P., Dukas, R., and McClelland, G.B. (2010) Lifetime changes in flight metabolic rate and muscle biochemistry of honeybees, Apis mellifera. J. Comp. Physiol. B. 180(1):45-55. [Abstract]|
  52. Wood, C.M., Walsh, P.J., Kajimura, M., McClelland, G.B., and Chew, S.F. (2010) The influence of feeding and fasting on plasma metabolites in the dogfish shark (Squalus acanthias). Comp Biochem Physiol A Mol Integr Physiol. 155(4):435-44.
  53. Craig, P.M., Hogstrand, C., Wood, C.M., and McClelland, G.B. (2009) Genetic endpoints of chronic waterborne copper exposure in a genomic model organism, the tropical fish, Danio rerio. Physiol. Gen. 40(1):23-33.
  54. Birceanu, O., McClelland, G.B. , Yang, Y.S. and Wilkie, M.P. (2009) A Failure of ATP Supply to Match ATP Demand: The Mechanism of Toxicity of the Lampricide, 3-trifluoromethyl-4-nitrophenol (TFM), Used to Control Sea Lamprey (Petromyzon marinus) Populations in the Great Lakes. Aquatic Toxicology 94:265-274.
  55. Brown, J.C.L., McClelland, G.B., Faure, P.A., Klaiman, J.M., and Staples, J.F. (2009) Examining the mechanisms responsible for lower ROS release rates in liver mitochondria from the long-lived house sparrow (Passer domesticus) and big brown bat (Eptesicus fuscus) compared to the short-lived mouse (Mus musculus). Mechanisms of Ageing and Development 130(8):467-476. [Abstract]|
  56. Fitzpatrick, J.L., Craig, P.M., Bucking, C., Balshine, S., Wood, C.M., McClelland, G.B. (2009) Sperm performance under hypoxic conditions in an intertidal fish (Porychthys notatus). Can. J. Zool. 87:464-469. [Abstract]|
  57. Craig, P.M., Galus, M., Wood, C.M., and McClelland, G.B. (2009) Dietary iron alters waterborne-copper induced gene expression in softwater acclimated zebrafish (Danio rerio). Am. J. Physiol.296:R362-R373. [Abstract]|
  58. Morash, A.J., Bureau, D. and McClelland, G.B. (2009) Dietary effects on the regulation of CPT I in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. B. 152:85-93. [Abstract]|
  59. Staples, J.F., Kajimura, M., Wood, C.M., Ip, Y.K., and McClelland, G.B. (2008) Enzymatic and mitochondrial responses to 5 months of aerial exposure in the slender lungfish (Protopterus dolloi). J. Fish Biol.73:608-622. [Abstract]|
  60. Ask, K., Labiris, R., Farkas, L., Moeller, A., Froese, A, Farncombe, T., McClelland, G., Inman, M., Gauldie J., Kolb, M. (2008) Comparison between conventional and "clinical" assessment of experimental lung fibrosis. J. Transl. Med. 6(1):16. [Abstract]|
  61. Morash, A.J., Kajimura, M., and McClelland, G.B. (2008) Intertissue regulation of carnitine palmitoyltransferase I (CPTI): Mitochondrial membrane properties and gene expression in rainbow trout (Oncorhychus mykiss). BBA-Biomembranes 1778:1382-1389. [Abstract]|
  62. Craig, P.M., Wood, C.M., and McClelland, G.B. (2007) Oxidative stress response and gene expression with acute copper exposure in zebrafish (Danio rerio). Am. J. Physiol. 293:R1882-R1892 [Abstract]|
  63. Craig, P.M., Wood, C.M., and McClelland, G.B. (2007) Gill membrane remodeling with softwater acclimation in Zebrafish (Danio rerio) Physiol. Genomics 30:53-60. [Abstract]|
  64. Tkatcheva, V., Franklin, N.M., McClelland, G.B., Smith, R.W., Holopainen, I.J., and Wood, C.M. (2007) Physiological and biochemical effects of lithium in rainbow trout. Arch. Environ. Contam. Toxicol. 53: 632-638. [Abstract]|
  65. McClelland, G.B., Craig, P.M., Dhekney, K., and DiPardo, S. (2006) Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio) J.Physiol. 577(2):739-751 [Abstract]|
  66. Schippers, M.-P., Dukas, R., Smith, R.W., Wang, J., Smolen, K and McClelland, G.B. (2006) Lifetime performance in foraging honey bees: behaviour and physiology J. Exp. Biol. 209: 3828-3836 [Abstract]|
  67. LeMoine, CMR, McClelland, GB, Lyons, CN, Mathieu-Costello, O, and Moyes, CD. (2006) Control of mitochondrial gene expression in the aging rat myocardium., Biochem. Cell Biol./Biochim. biol. cell. 84(2): 191-198 [Abstract]|
  68. McClelland, G.B., Dalziel, A., Fragoso, N., and Moyes, C.D. (2005) Muscle remodeling in relation to blood supply: implications for seasonal changes in mitochondrial enzymes (2005) J. exp. Biol. 208:515-522 [Abstract]|

  69. McClelland, G.B. Fat to the fire: the regulation of lipid oxidation with exercise and environmental stress. (2004) Comp. Biochem. Physiol.139(3):443-460 [Abstract]|
  70. Butz, C.E., McClelland, G.B., and Brooks, G.A. (2004) MCT1 confirmed in rat striated muscle mitochondria. J. Appl. Physiol.97: 1059-1066
  71. [Abstract]|
  72. McClelland, G.B., Michaud, D., Kraft, C., Russell, J.C., Mueller, C.R., and Moyes, C.D. (2004) Leptin and the Control of Respiratory Gene Expression In Muscle. Biochem. Biophys. Acta. 1688:86-93 [Abstract] |
  73. McClelland, G.B., Khanna, S., Butz, C.E., Gonzalez, G. and Brooks, G.A. (2003) Peroxisomal membrane monocarboxylate transporters (MCT): Evidence for a redox shuttle system? Biochem. Biophys. Res. Comm. 304:130-135 [Abstract]|
  74. McClelland, G.B., and Brooks, G.A. (2002) Changes in MCT 1, MCT 4 and LDH expression are tissue specific in rats after long-term hypobaric hypoxia. J. Appl. Physiol. 92:1573-1584 [Abstract]|
  75. McClelland, G.B., Hochachka, P.W., Reidy, S.P., and Weber, J.-M. (2001) High-altitude acclimation increases the triacylglycerol / fatty acid cycle at rest and during exercise. Am. J. Physiol. 281:E537-E544. [Abstract]|
  76. Burness, G.P., McClelland, G.B., Wardrop, S.L. and Hochachka, P.W. (2000) Effect of brood size manipulation on offspring physiology: An experiment with passerine birds. J. exp. Biol. 203:3513-3520. [Abstract] |
  77. McClelland, G.B., Hochachka, P.W., and Weber, J.-M. (1999). Effects of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in rats. Am. J. Physiol. 277:E1095-E1102. [Abstract] |
  78. McClelland, G.B., Hochachka, P.W., and Weber, J.-M. (1998). Carbohydrate utilization during exercise after high-altitude acclimation: A new perspective. Proc. Natl. Acad. Sci., USA. 95(17): 10288:10293. [Abstract] |
  79. Hochachka, P.W., McClelland, G.B., Burness, G.P., Staples, J.F., and Suarez, R.K. (1998). Integrating metabolic pathway fluxes and gene-to-enzyme expression rates. Comp. Biochem. Physiol. 120B(1): 17-27. [Abstract] |
  80. Hochachka, P.W. and McClelland, G.B. (1997) Cellular metabolic homeostasis during large scale changes in ATP turnover rates in muscle. J. exp. Biol. 200: 381-386.
  81. Weber. J.-M., Brichon, G., Roberts, T., McClelland, G., Saucedo, C., Weibel, E.R., and Taylor, C.R. (1996).Design of the oxygen and substrate pathways IV. Partitioning energy provision from fatty acids. J. exp. Biol. 199: 1667-1674.
  82. McClelland, G., Zwingelstein, G., Weber, J.-M., and Brichon, G. (1995). Tissue and plasma lipids of two Mediterranean fishes, the Sea Bream (Chrysophyrys auratus) and the Sea Bass (Dicentrarchus labrax). Can. J. Fish. Aquat. Sci. 52(1):161 170. [Abstract]|
  83. McClelland, G., Zwingelstein, G., Taylor, C.R., and Weber, J.-M. (1995). Effect of exercise on the plasma NEFA composition of dogs and goats:mammalian species with different aerobic capacities and diet. LIPIDS 30(2):147-153. [Abstract]|
  84. McClelland, G., Zwingelstein, G., Taylor, C.R., and Weber, J.-M. (1994). Increased capacity for circulatory fatty acid transport in a highly aerobic mammal. Am. J. Physiol. 266 (35):R1280 - R1286. [Abstract] |

Grant B. McClelland - McMaster University - Department of Biology - 1280 Main St. West Hamilton, ON L8S 4K1 Canada 
Office: 905.525.9140 x24266 - Lab: 905.525.9140 x23170 - Fax: 905.522.6066 | Grant can be e-mailed at grantm [at] mcmaster [dot] ca