Grant McClelland index MacMaster
montgolfiere hamster    
Hypoxia and Altitude  

Adaptation to high altitude has fascinated physiologists for over 130 years, since Paul Bert (1833-1886) proved that the deleterious effects on animals were the result of low partial pressures of oxygen, but metabolic adaptations to hypoxia have been difficult to demonstrate.

To examine adaptations to this potent stressor we use a powerful comparative approach using related species from the genus Phyllotis from the Andes and Peromyscus species from North America along with traditional models to examine acclimation to hypoxia.

Sample publications:

Schippers, M.-P., Ramirez, O., Arana, M., Bernal, P.P., and McClelland, G.B. (2012) Increase in carbohydrate utilization in high-altitude Andean mice. Current Biology. 22 (24):2350–2354.

Cheviron, Z.A., Bachman, G.C., Connaty, A.D., McClelland, G.B., Storz, J.F. (2012) Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice. Proc. Natl. Acad. Sci., USA., 109(22): 8635-40.

Lau, D., Mahalingam, S., Connaty, A.D., Wall, N., Cheviron, Z.A., Storz, J.F., Scott, G.R., and McClelland, G.B. (2017) Acclimation to hypoxia increases carbohydrate use during exercise in high-altitude deer mice. Am. J. Physiol. 312: R400–R411

Beaudry, J.L., and McClelland, G.B. (2010) Thermogenic responses in CD-1 mice after combined chronic hypoxia and cold acclimation. Comp. Biochem. Physiol. B. 157:301-309.

Hypoxia and altitude research in the McClelland Lab has been funded by the National Sciences and Engineering Council of Canada (NSERC), the Ontario Early Researcher Award, and the National Science Foundation  
  National Science Foundation  
Grant B. McClelland - McMaster University - Department of Biology - 1280 Main St. West Hamilton, ON L8S 4K1 Canada 
Office: 905.525.9140 x24266 - Lab: 905.525.9140 x23170 - Fax: 905.522.6066 | Grant can be e-mailed at grantm [at] mcmaster [dot] ca