Grant McClelland index MacMaster
Oxidative Stress Oxidative stress and toxigenomics  
Animals face high levels of oxidative stress due to anthropomorphic increased in pollutants in their environment. We are using zebrafish, lamprey, killifish, mussels, and crabs as a model species to extend the Biotic Ligand Model to chronic metal exposures (Cu) and to biochemical & genomic endpoints.

Sample publications:

Kulesza, A., Leonard, E.M., and McClelland, G.B. (2020) Influence of 96h sub-lethal copper exposure on aerobic scope and recovery from exhaustive exercise in killifish (Fundulus heteroclitus). Aquatic Toxicology. 218:105373

Craig, P.M., Wood, C.M., and McClelland, G.B. (2010) Water Chemistry alters gene expression and physiological endpoints of chronic waterborne copper exposure in zebrafish, Danio rerio. Environ. Sci. Tech. 44: 2156-2162

Craig, P.M., Wood, C.M., and McClelland, G.B. (2007) Oxidative stress response and gene expression with acute copper exposure in zebrafish (Danio rerio). Am. J. Physiol. 293:R1882-R1892
Research in the McClelland Lab is currently being funded by the National Sciences and Engineering Council (NSERC), PREA and a CFI New Opportunities Grant.  
  Canada Foundation for Innovation  
Grant B. McClelland - McMaster University - Department of Biology - 1280 Main St. West Hamilton, ON L8S 4K1 Canada 
Office: 905.525.9140 x24266 - Lab: 905.525.9140 x23170 - Fax: 905.522.6066 | Grant can be e-mailed at grantm [at] mcmaster [dot] ca