Exit Seminar from Lindyann Lessey
This week we will have an exit seminar from Lindyann Lessey (Daniel lab)!
There will be coffee and snacks before the seminar. Please bring your own mug.
Thursday 23 Jan, 4:00PM, HSC 1A5 and on zoom (Passcode: cElegans).
Role of the transcription factor Kaiso in intestinal inflammation and colon cancer
Inflammatory bowel disease (IBD) is very prevalent in Canada and is characterized by chronic inflammation of the gastrointestinal tract and increases the likelihood of developing colitis-associated cancer (CAC) in IBD sufferers. It remains to be determined how chronic inflammation in IBD influences the development of CAC mutational signatures or molecular phenotypes. Our lab previously reported that intestinal-specific overexpression of the transcription factor Kaiso induces a chronic inflammatory phenotype characterized by crypt hyperplasia, increased infiltration and activation of neutrophils, and increased permeability of the intestinal epithelium. However, the molecular mechanisms involved in Kaiso’s inflammatory phenotype is yet to be fully elucidated. Interestingly, a similar inflammatory phenotype was observed following the loss of p120ctn, a binding partner and inhibitor of Kaiso suggesting that Kaiso and p120ctn have opposing roles in intestinal diseases. Nevertheless, the role(s) of Kaiso and p120ctn, if any, in IBD and CAC have not been fully explored. The goal of my project was to identify the molecular mechanism and signalling pathways involved in the Kaiso-induced inflammatory phenotype and determine the role(s), if any, that Kaiso and p120ctn play in IBD and CAC progression.
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